Elevated serum free light chains are associated with inferior event free and overall survival in Hodgkin lymphoma
نویسندگان
چکیده
منابع مشابه
Predictors of early response and event-free survival in Hodgkin lymphoma (HL): PET versus CT imaging.
8006 Background: Early PET imaging has emerged as a predictor of EFS in HL, but comparisons of early response assessment by PET vs. CT are limited. Children's Oncology Group (COG) study AHOD0031 was designed to evaluate the paradigm of early-response-based treatment intensity. PET and CT scans were obtained after 2 cycles of ABVE-PC, allowing direct comparison of imaging modalities. We examined...
متن کاملQuantitation of serum free light chains.
under usual artificial light conditions, and storage of unproc-essed whole blood without antico-agulants at room temperature on the bench. Additionally, we tested the effect of multiple freeze-thaw cycles. 25(OH)–vitamin D 3 measurements were performed on a Cobas E601 an-alyzer (Roche), using the vitamin D 3 (25-OH) assay as recommended by the manufacturer. Samples from each storage experiment ...
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Mutations in codon D816 of the KIT gene represent a recurrent genetic alteration in acute myeloid leukemia (AML). To clarify the biologic implication of activation loop mutations of the KIT gene, 1940 randomly selected AML patients were analyzed. In total, 33 (1.7%) of 1940 patients were positive for D816 mutations. Of these 33 patients, 8 (24.2%) had a t(8;21), which was significantly higher c...
متن کاملElevated serum free light chains predict cardiovascular events in type 2 diabetes.
OBJECTIVE Elevated polyclonal serum immunoglobulin free light chains (FLCs; combined FLCκ+FLCλ [cFLC]) are associated with adverse clinical outcomes and increased mortality; we investigated cFLC and cardiovascular disease (CVD) events in type 2 diabetes. RESEARCH DESIGN AND METHODS In a cohort study of 352 south Asian patients with type 2 diabetes, serum cFLC, high-sensitivity C-reactive prot...
متن کاملMeasurement of immunoglobulin free light chains in serum.
but the active/latent isoform proportions were similar (Fig. 1A). Platelet aggregation during clotting (6) may have caused these differences. MMP expression was lower in K 2 E plasma than in LH plasma [14 (3) vs 25 (4) g/L; P Ͻ0.05; Fig. 1A, lane 4 vs lane 5]. The concentrations of MMP-9 forms decreased significantly with increasing amounts of K 2 E during PB collection, whereas MMP-2 was incr...
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ژورنال
عنوان ژورنال: American Journal of Hematology
سال: 2011
ISSN: 0361-8609
DOI: 10.1002/ajh.22168